The 2-Minute Rule for Indazole Products
Substitution at R3 by using a halogen or alkoxy group (74f–74i) resulted in a slight increase in mobile potency While using the halide analogs (74g–h) showing highest the potency in the group. Further optimization triggered the discovery of 74i–j, with 74k as one of the most active compound in the collection (pIC50 = 6.seventy seven) with fan